Polyethylene glycol phospholipids encapsulated silicon 2,3-naphthalocyanine dihydroxide nanoparticles (SiNcOH-DSPEPEG(NH2) NPs) for single NIR laser induced cancer combination therapy

Currently, the combination of photothermal therapy (PTT) and photodynamic therapy (PDT) has emerged as a powerful technique for cancer treatment. However, most examples of combined PTT and PDT reported use multi-component nanocomposites under excitation of separate wavelength, resulting in complex treatment process. In this work, a novel theranostic nanoplatform (SiNcOH-DSPE-PEG(NH₂) NPs) has been successfully developed by coating silicon 2,3-naphthalocyanine dihydroxide (SiNcOH) with DSPE-PEG and DSPE-PEG-NH₂ for photoacoustic (PA) imaging-guided PTT and PDT tumor ablation for the first time. The as-prepared single-agent SiNcOH-DSPE-PEG(NH₂) NPs not only have good water solubility and biocompatibility, but also exhibit high photothermal conversion efficiency and singlet oxygen generation capability upon 808 nm NIR laser irradiation. In addition, owing to their high absorption at NIR region, the SiNcOH-DSPE-PEG(NH₂) NPs can also be employed as an effective diagnostic nanoagent for photoacoustic (PA) imaging. In vitro and in vivo experimental results clearly indicated that the simultaneously combined PTT and PDT under the guidance of PA imaging with single NIR laser excitation can effectively kill cancer cells or eradicate tumor tissues. Taking facile synthesis and high efficiency in cancer treatment by SiNcOH-DSPE-PEG(NH₂) NPs into consideration, our study provides a promising strategy to realize molecular imaging-guided combination therapy.     

A novel aptasensor based on 3D-inorganic hybrid composite as immobilized substrate for sensitive detection of platelet-derived growth factor

A novel electrochemical detection approach for platelet-derived growth factor(PDGF) via "sandwich"structure is reported in this paper. 3D-4MgCO_3 Mg(OH)_2 4H_2O-Au NPs inorganic hybrid composite was utilized as immobilized substrate for sensitive PDGF detection and Pt-Au bimetallic nanoparticles were labelled on PDGF aptamer to indirectly detect PDGF for the first time. The proposed aptasensor exhibited a high catalytic efficiency towards reduction of H_2O_2, hence the sensitive detection of PDGF was achieved.Results showed that the aptasensor exhibited excellent linear response to PDGF, in the range of 0.1 pg/m L–10 ng/m L(4 fmol/L–400 pmol/L), with detection limit of 0.03 pg/m L(1.2 fmol/L).     

地方工科院校《功能高分子材料》课程教学内容的精选与实践

随着材料学的蓬勃发展,功能高分子材料的种类及用途日益繁多,因而《功能高分子材料》课程教学内容涵盖也不断延伸。针对地方工科院校高分子材料与工程专业人才培养的机制和目标,作者探索实践了如何以学生为本、以社会和行业的人才需求为导向,紧密联系地方经济与行业格局,因时因势对课程教学内容进行优化和完善。在此基础上,通过科学合理的教学实践,使学生既能牢固掌握功能高分子材料的基础知识,又能了解本领域最前沿的科学发展动态,拓宽学习思路,提高学习积极性,增强对专业的认可与对行业的期待。     

Hydrothermal synthesis of peony-like CuO micro/nanostructures for high-performance lithium-ion battery anodes

The peony-like CuO micro/nanostructures were fabricated by a facile hydrothermal approach. The peonylike CuO micro/nanostructures about 3-5 μm in diameter were assembled by CuO nanoplates. These CuO nanoplates, as the building block, were self-assembled into multilayer structures under the action of ethidene diamine, and then grew into uniform peony-like CuO architecture. The novel peony-like CuO micro/nanostructures exhibit a high cycling stability and improved rate capability. The peony-like CuO micro/nanostructures electrodes show a high reversible capacity of 456 mAh/g after 200 cycles, much higher than that of the commercial CuO nanocrystals at a current 0.1 C. The excellent electrochemical performance of peony-like CuO micro/nanostructures might be ascribed to the unique assembly structure, which not only provide large electrode/electrolyte contact area to accelerate the lithiation reaction, but also the interval between the multilayer structures of CuO nanoplates electrode could provide enough interior space to accommodate the volume change during Li~+ insertion and de-insertion process.     

A review of transition metal chalcogenide/graphene nanocomposites for energy storage and conversion

Recent advances in the applications of transition metal chalcogenides/graphene (TMC/graphene) nanocomposites in future energy storage and conversion are reviewed. The synthesis processes and structures of TMC/graphene, workingpriciple of evergy energy device, and the electrochemical performances are summarized.     

《高分子材料表面与界面》教学的探讨——海外教师主导的研究生全英文课程教学经验

浙江大学海外教师主导的研究生全英文课程建设项目于2013年开始进行建设,高分子科学与工程学系借此契机,在原研究生课程《高分子材料表面与界面》的基础上,邀请德国海德堡大学M.Grunze教授进行全英文教学。本课程旨在建设与国际接轨的,具有基础性、前沿性、交叉性且受益面广的全英文课程,提高高分子专业研究生的专业水平,扩大学生知识面,提高英语交流水平,同时培养一支具有国际化教学能力的中青年师资队伍。本文就该课程三年建设期以来的教学内容形式、课堂管理、学生学习体验等方面进行了总结,并针对研究生学习过程中存在的问题,结合当前我国研究生的基本现状,提出了一系列教学经验。     

生物降解高分子——一类重要的生物材料 2.生物相容性及脂肪族聚酯的表面改性

脂肪族聚酯是一类越来越受到关注的生物可降解生物材料。由于所有的医疗和药物制品在临床应用时都将不同程度地同机体组织或血液接触,而其表面又将是首先与机体组织或血液接触的部分,因此脂肪族聚酯医用制品的表面生物相容性更是同制品生物安全性和有效性有直接关系的性质。本文在分析脂肪族聚酯自身特性及对其制品表面生物相容性影响因素的基础上,介绍了采用物理、化学和等离子体处理方法对脂肪族聚酯制品表面生物相容性的改进。在分析和讨论各表面改性方法优点的同时,也指出了该法所存在的缺点、不足和应用的局限性。从而可为提高具体的脂肪族聚酯医用制品的表面生物相容性提供可供选择的表面改性方法。     

基于聚合物添加剂谱库的缓冲盐中塑料药品包装材料难挥发可溶出物的快速分析方法研究

采用超高效液相色谱-四极杆飞行时间质谱(UPLC-QTOF-MS),结合基于UNIFI软件建立的174种聚合物添加剂的谱库,实现了塑料药品包装材料中难挥发可溶出物(Extractables)的快速筛查和准确定量。样品经氯仿萃取后,以甲醇和0.1%甲酸水溶液为流动相在CORTECS C18(2.1 mm×100 mm,1.6μm)色谱柱上进行分离,在质谱电喷雾正离子模式下,UPLC-QTOF-MS进行筛查和定量分析。结果表明,浸泡60 d缓冲盐(25℃)中检出4种物质,利用谱库筛查确定其中1种物质是邻苯二甲酸二异癸酯(DIDP),采用外标法定量,测得其溶出量为1.98μg/L;其余3种物质可通过精确质量数、MSE谱图等进行推断定性,利用结构与质量数相近的邻苯二甲酸二环己酯(DCHP)为内标进行定量,3种提取物的总含量为10.80μg/L。利用DIDP进行回收率实验,5,10,20μg/L 3个加标水平的回收率为90.1%~97.1%,相对标准偏差(RSD,n=6)不大于3.7%。该方法快速、准确、灵敏,适用于药品包装材料的安全性考察。     

磁性聚苯乙烯-氯甲基苯乙烯材料的合成及其对蒽的吸附性能研究

采用4-氯甲基苯乙烯(VBC)为单体,二乙烯基苯为交联剂(DVB),以磁性γ-甲基丙烯酰氧基丙基三甲氧基硅烷(MPS)修饰硅胶微球为核,在偶氮二异丁腈(AIBN)引发下,以甲苯和聚乙二醇2000的混合溶液(质量比1∶2)为联合致孔剂,原位聚合制备了磁性聚苯乙烯-氯甲基苯乙烯材料(Fe3O4@Si O2@DVBVBC)。通过傅立叶红外光谱(FT-IR)、X-射线衍射(XRD)和氮气物理吸附对该材料的结构和组成特性进行了表征。以蒽为考察对象,对制备材料的吸附性能进行了考察,发现单体和交联剂的质量比对材料的吸附能力影响较大。当单体和交联剂的质量比为1∶4时,对蒽的吸附性能最佳。材料的孔结构会影响吸附平衡时间。制备的材料对蒽能够在30 min内达到吸附平衡且吸附率达95%。该材料对多环芳烃化合物的吸附主要依靠疏水作用。吸附动力学研究表明,材料对蒽的吸附性能对准一级动力学方程具有较好的拟合程度。采用2 mL乙腈涡旋15 min可将99%的蒽洗脱下来。     

固相萃取/高效液相色谱-串联质谱法同时检测多类食品中二甲基黄、二乙基黄含量

建立了豆干、辣椒酱、豆腐乳、腐竹和饼干等样品中二甲基黄和二乙基黄残留量的液相色谱-串联质谱分析方法。基于二甲基黄和二乙基黄的化学结构特性,采用乙腈溶液提取。提取液酸化后经Bond Elut Plexa PCX阳离子交换树脂固相萃取净化,吹干复溶后,使用反相C_(18)色谱柱分离,电喷雾串联四极杆质谱正离子化多反应监测(MRM)模式检测。二甲基黄和二乙基黄的方法定量下限均为0.50μg/kg。对5种不同基质样品进行二甲基黄和二乙基黄0.50,5.0,80μg/kg 3个浓度水平的加标回收实验,得到二甲基黄和二乙基黄的平均回收率分别为76.4%~93.0%和76.1%~92.4%;相对标准偏差分别为1.7%~6.3%和1.9%~7.4%,可以满足食品中二甲基黄和二乙基黄快速筛查和定量分析的要求。